Infectious mononucleosis — UKMLA Revision Notes

Infectious mononucleosis is an important clinical condition in Infection & Microbiology that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Infectious mononucleosis as outlined in current NICE guidelines.

Key Facts

Infectious mononucleosis is a key condition on the GMC UKMLA Content Map
Commonly tested in the Infection & Microbiology section of the UKMLA Applied Knowledge Test
Understand the pathophysiology, clinical features, investigations, and management
NICE guidelines provide the evidence base for management decisions
Consider differential diagnoses and red flag symptoms in clinical scenarios

Investigations

Blood cultures (×2)
FBC, CRP, procalcitonin
Urine MC&S
CXR
Throat/wound swabs
Serology

Management

Empirical antibiotics per local guidelines
Source control (drainage, removal of infected device)
IV to oral switch when clinically stable
Infection control measures (isolation if required)
Microbiology advice
Antibiotic stewardship

Practice 2+ Infectious mononucleosis Questions

Test your knowledge with SBA questions on Infectious mononucleosis and all 430 UKMLA Content Map conditions. Instant feedback, NICE guideline explanations, and spaced repetition included.