Endocrinology3 UKMLA questions
Graves' disease — UKMLA Revision Notes
Graves' disease is an important clinical condition in Endocrinology that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Graves' disease as outlined in current NICE guidelines.
Key Facts
- Graves' disease is a key condition on the GMC UKMLA Content Map
- Commonly tested in the Endocrinology section of the UKMLA Applied Knowledge Test
- Understand the pathophysiology, clinical features, investigations, and management
- NICE guidelines provide the evidence base for management decisions
- Consider differential diagnoses and red flag symptoms in clinical scenarios
Investigations
- TFTs (TSH, T4, T3)
- Fasting glucose/HbA1c
- Cortisol (9am)
- Pituitary MRI
- Bone profile
- Urine/serum osmolality
Management
- Hormone replacement/suppression as indicated
- Lifestyle modification (diet, exercise)
- Monitor for complications
- Endocrinology outpatient follow-up
- Patient education and self-monitoring
- Surgical referral if indicated